GAMBARAN AWAL EFEK SAMPING VAKSIN SINOVAC-CORONAVAC PADA PETUGAS KESEHATAN DI KABUPATEN KEPULAUAN SANGIHE
PRELIMINARY DATA ON SINOVAC-CORONAVAC VACCINE’S SIDE EFFECTS AMONG HEALTHWORKER IN SANGIHE ISLAND DISTRICT
Abstract
Efek samping vaksin COVID-19 menjadi informasi yang sangat penting diketahui untuk meyakinkan masyarakat dalam rangka peningkatan cakupan vaksinasi. Penelitian ini bertujuan melakukan studi independen untuk mengetahui efek samping Sinovac-CoronaVac pada petugas kesehatan. Metode penelitian berupa cross-sectional pada Juni-Desember 2021. Kuesioner berisi pertanyaan tentang data demografi, anamnesis, dan efek samping vaksin Mayoritas partisipan tidak merasakan efek samping apapun, 61,8 persen setelah dosis 1 dan 88,1 persen setelah dosis 2. Efek samping yang dirasakan umumnya ringan seperti mengantuk (14,7 persen), tidak enak badan (6,5 persen), sakit di lokasi suntikan (4,8 persen), sakit kepala (5,8 persen), demam (5,1 persen), nafsu makan meningkat (3,8 persen), letih/lesu (3,1 persen), bengkak di lokasi suntikan (2,4 persen), dan nyeri ulu hati (0,7 persen). Terdapat perbedaan proporsi efek samping yang signifikan menurut kelompok umur dan riwayat alergi. Efek samping vaksin Sinovac-CoronaVac tergolong ringan bahkan tanpa efek samping, sehingga masyarakat tidak perlu ragu untuk mendapatkan vaksinasi COVID-19.
The study of COVID-19 vaccine side effects is very important to convince the community to increase vaccination coverage. This study aimed to conduct an independent study to determine the side effects of Sinovac-CoronaVac among health workers. The cross-sectional research method was carried out in June-December 2021 on health workers. The questionnaire contains questions about demographic data, medical anamneses, and vaccine side effects. The majority of participants did not feel any side effects, 61.8 percent after dose 1 and 88.1 percent after dose 2. The side effects felt were generally mild, including increased sleep (14.7 percent), feeling unwell (6.5 percent), injection site pain (4.8 percent), headache (5.8 percent), fever (5.1 percent), increased appetite (3.8 percent), fatigue (3.1 percent), injection site swelling (2.4 percent), and nausea (0.7 percent). There was a significant difference in the proportion of side effects according to age group and allergy history. The side effects of the Sinovac-CoronaVac vaccine are mild and even without side effects, so people don't need to hesitate to get the COVID-19 vaccination.
Downloads
References
Amit, S. et al., 2021. Postvaccination COVID-19 among Healthcare Workers, Israel. Center for Disease Control and Prevention, (online), Volume 27, No. 4, https://wwwnc.cdc.gov/eid/article/27/4/21-0016_article
Centers for Disease Control and Prevention (CDC). 2021. The Janssen COVID-19 Vaccine’s Local Reactions, Systemic Reactions, Adverse Events, and Serious Adverse Events. (Online), https://www.cdc.gov/vaccines/covid-19/info-by-product/janssen/reactogenicity.html
Centers for Disease Control and Prevention (CDC). 2021. Local Reactions, Systemic Reactions, Adverse Events, and Serious Adverse Events: Pfizer-BioNTech COVID-19 Vaccine. (online), https://www.cdc.gov/vaccines/covid-19/info-by-product/pfizer/reactogenicity.html
CNN Indonesia. 25 Maret 2021. Alasan Mengantuk Usai Vaksinasi Covid-19. (online), https://www.cnnindonesia.com/gaya-hidup/20190513112146-255-394337/alasan-mengantuk-usai-vaksinasi-covid-19, diakses 4 Oktober 2021
Kadali RAK, et al. 2021. Side effects of BNT162b2 mRNA COVID-19 vaccine: A randomized,cross-sectional study with detailed self-reported symptoms fromhealthcare workers. International Journal of Infectious Diseases, 106:376-381. https://doi.org/10.1016/j.ijid.2021.04.047
Kementerian Kesehatan RI. 2021. Petunjuk Teknis Pelaksanaan Vaksinasi dalam Rangka Penanggulangan Pandemi Corona Virus Disease 2019 (COVID-19). [Accessed February 20, 2021]. Available from: Final SK Dirjen Juknis Vaksinasi COVID-19 02022021.pdf (kemkes.go.id)
Komnas KIPI Indonesia. 2021. Komnas KIPI: Sejauh Ini, Semua Laporan KIPI Bersifat Ringan. Diakses dari Komnas KIPI: Sejauh Ini, Semua Laporan KIPI Bersifat Ringan - Berita Terkini | COVID19.go.id. 24 Februari 2021
LaMorte WW. Sample Sizes for Two Independent Samples, Continuous Outcome. 2020. Boston University School of Public Health.
Lemeshow S, David H., Klar J. (1990). Adequacy of Sample Size in Helath Studies. 1990. Yogyakarta: Gajah Mada University Press.
McGurnaghan SJ, et al. 2021. Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland. The Lancet, 9(2):82-93. https://doi.org/10.1016/S2213-8587(20)30405-8
McKeigue PM, et al. 2020. Rapid Epidemiological Analysis of Comorbidities and Treatments as risk factors for COVID-19 in Scotland (REACT-SCOT): A population-based case-control study. PLoS Med, 17(10): e1003374. https://doi.org/10.1371/journal.pmed.1003374
Riad A. et al. 2021. Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic. J. Clin. Med, 10(7):1428. https://doi.org/10.3390/jcm10071428
Wang X. et al. 2021. Risk Factors for COVID-19 in Patients with Hypertension. Hindawi, 2021: 1-9. https://doi.org/10.1155/2021/5515941
WHO. 2021. Interim recommendations for use of the inactivated COVID-19 vaccine, CoronaVac, developed by Sinovac-CoronaVac. Genewa, (online), https://www.who.int/publications/i/item/WHO-2019-nCoV-vaccines-SAGE_recommendation-Sinovac-CoronaVac-CoronaVac-2021.1
Wu Q. et al. 2021. Evaluation of the safety profile of COVID-19 vaccines: a rapid review. BMC Medicine, 19(173):1-16: https://doi.org/10.1186/s12916-021-02059-5
